Technology
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High-shear synthesis forces every coupling to completion in seconds, on a fraction of the reagent conventional peptide chemistry needs. This is how it works, and how it grows.
Our Approach
Most peptide synthesis is a fight against waste. Every step floods the reaction with reagent to force it along, then throws most of that reagent away. Amidera removes the fight. Control the reaction tightly enough and it runs to completion on its own, faster, cleaner, and on a fraction of the material.
MECHANISM
Three variables control every coupling.
Conventional synthesis compensates for slow, incomplete reactions by flooding every step with reagent, then discarding most of it. Amidera works the other way. Control three variables tightly enough and each coupling runs to completion on its own, in seconds, with little left to wash away.
[01]
Mix hard
High-shear stirring at 1,200 rpm keeps reagents fully in contact with the resin, so each coupling reaches completion in 10 to 30 seconds rather than the minutes conventional stirring needs. Speed here isn't the goal in itself, it's what makes the reagent savings possible.
[02]
Heat, controlled
Holding the reaction at 90°C accelerates coupling further, but the control is the point, not the heat. Uncontrolled temperature degrades the growing chain and drives side reactions. Held precisely, it speeds the reaction while leaving the peptide intact.
[03]
Use less
Because each coupling finishes cleanly, it needs as little as 2.0 equivalents of amino acid and 5% piperidine for deprotection, against the 5.0 equivalents or more conventional synthesis relies on. Less reagent in means less waste out, at every single step of the chain.
THE SCALE-OUT MODEL
Others scale one reactor up. We scale out.
Conventional capacity means bigger vessels, and bigger vessels change the chemistry, forcing re-validation at every jump in size. Amidera's process runs in a small, fixed reactor. To make more, you add more of the same unit rather than building a larger one. The chemistry never changes, only the count.
A single working reactor unit. A 29-residue glycopeptide synthesised in full at 20 mL scale, reproduced across triplicate runs and confirmed under the microscope.
Parallel arrays of identical reactor units on shared reagent infrastructure, under one software control layer, with a process-data layer to sequence and prioritise runs.
THE REACTOR
Let's Get to Work
