Science & Publications
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Every performance figure on this site traces back to peer-reviewed work. The papers are listed here in full.
Our Standard
Amidera was built out of published research, and we hold to that standard. Every number on this site comes from peer-reviewed work.
Peer-Reviewed
Nine peer-reviewed papers, published across Organic Process Research and Development, the Journal of Medicinal Chemistry, Organic and Biomolecular Chemistry, the European Journal of Organic Chemistry, Chemistry: A European Journal, and Frontiers in Molecular Biosciences.
References
SYNTHESIS & EFFICIENCY
[01]
Stirring Peptide Synthesis to a New Level of Efficiency
Naoum, J. N.; Alshanski, I.; Mayer, G.; Strauss, P.; Hurevich, M. · Org. Process Res. Dev. · 2022
Demonstrated: couplings and deprotection in 10 to 30 seconds, on 2 equivalents of amino acid and 5% piperidine.
GLYCOPEPTIDES
[02]
Expeditious Synthesis of a Glycopeptide Library
Ben Abba Amiel, D.; Hurevich, M. · Eur. J. Org. Chem. · 2022
Demonstrated: synthesis of O-glycosylated peptides with on-resin deacetylation.
[03]
Accelerated Solid-Phase Synthesis of Glycopeptides Containing Multiple N-Glycosylated Sites
Strauss, P.; Nuti, F.; Quagliata, M.; Papini, A. M.; Hurevich, M. · Org. Biomol. Chem. · 2023
Demonstrated: peptides of up to 19 residues with up to three N-glycosylation sites, above 45% crude purity, on 30-second couplings.
[04]
Expeditious Synthesis of Multiglycosylated Peptides for Sensing of Listeria Monocytogenes
Ben Abba Amiel, D.; Okshtein, H.; Alshanski, I.; Hayouka, Z.; Yitzchaik, S.; Hurevich, M. · J. Med. Chem. · 2025
Demonstrated: up to three O-glycosylation sites with on-resin deacetylation, reaching 80% crude purity on 1.2 equivalents.
[05]
Expeditious Synthesis of Multiglycopeptides with Heterogeneous Glycan Cores Derived from an α-Dystroglycan Mucin-like Domain
Ben Abba Amiel, D.; Hurevich, M. · Org. Biomol. Chem. · 2026
Demonstrated: heterogeneous multi-glycosylated peptides at over 60% crude purity.
PHOSPHOPEPTIDES
[06]
Accelerated Multiphosphorylated Peptide Synthesis
Grunhaus, D.; Molina, E. R.; Cohen, R.; Stein, T.; Friedler, A.; Hurevich, M. · Org. Process Res. Dev. · 2022
Demonstrated: accelerated synthesis of multiphosphorylated peptides containing up to six phosphorylation sites.
[07]
Specific Phosphorylation Patterns Control the Interplay between Aggregation and Condensation of Tau-R4 Peptides
Bressler, S. G.; Grunhaus, D.; Aviram, A.; Rüdiger, S. G. D.; Hurevich, M.; Friedler, A. · Org. Biomol. Chem. · 2025
Demonstrated: up to triple-phosphorylated, fluorescently labelled peptides of up to 23 residues.
GLYCAN CHEMISTRY
[08]
Accelerated Solid Phase Glycan Synthesis: ASGS
Bakhatan, Y.; Alshanski, I.; Chan, C. K.; Lo, W. C.; Lu, P. W.; Liao, P. H.; Wang, C. C.; Hurevich, M. · Chem. Eur. J. · 2023
Demonstrated: accelerated glycosylation and synthesis of disaccharides.
METHOD OVERVIEW
[09]
Stirring Glycopeptides Away from the Constraints of Solid-Phase Synthesis Misconceptions
Ben Abba Amiel, D.; Gilon, C.; Hurevich, M. · Front. Mol. Biosci. · 2026
Demonstrated: the principles behind the high-shear method, set out in full.
Patents & Licensing
Licensed through Yissum. Protected by three patent families.
The high-shear platform originated in the laboratory of Professor Mattan Hurevich at the Hebrew University of Jerusalem, with Professor Chaim Gilon among its scientific minds. It is licensed to Amidera through Yissum, the university's technology transfer company.
Hurevich laboratory, Hebrew University of Jerusalem.
Three patent families. Licensed to Amidera through Yissum.
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